Conjugates of Iron-Transporting N-Hydroxylactams with Ciprofloxacin |
| |
Authors: | Olga Bakulina Anton Bannykh Ekaterina Levashova Mikhail Krasavin |
| |
Institution: | 1.Saint Petersburg State University, 26 Universitetskii Prospect, 198504 Peterhof, Russia; (O.B.); (A.B.); (E.L.);2.Immanuel Kant Baltic Federal University, 236041 Kaliningrad, Russia |
| |
Abstract: | Screening of a library of novel N-hydroxylactams amenable by the Castagnoli-Cushman reaction identified four lead compounds that facilitated 55Fe transport into P. aeruginosa cells (one of these synthetic siderophores was found to be as efficient at promoting iron uptake as the natural siderophores pyoverdine, pyochelin or enterobactin). Conjugates of the four lead siderophores with ciprofloxacin were tested for antibacterial activity against P. aeruginosa POA1 (wild type) and the ∆pvdF∆pchA mutant strain. The antibacterial activity was found to be pronounced against the ∆pvdF∆pchA mutant strain grown in CAA medium but not for the POA1 strain. This may be indicative of these compounds being ‘Trojan horse’ antibiotics. Further scrutiny of the mechanism of the antibacterial action of the newly developed conjugates is warranted. |
| |
Keywords: | Castagnoli-Cushman reaction cyclic hydroxamic acids siderophores bacterial iron transport Trojan horse antibiotics |
|