Study of chloroquine binding to melanins by pyrolysis-gas chromatography and electron spin resonance spectroscopy |
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| Affiliation: | 1. School of Mechatronic Engineering, Xi''an Technological University, Xi''an 710021, China;2. Institute of Engineering and Technology, Department of Hydraulics and Hydraulic and Pneumatic Systems, South Ural State University, Lenin Prospect 76, Chelyabinsk, 454080, Russian Federation;3. Department of Process Engineering, Research and Development Department, Shazand-Arak Oil Refinery Company, Arak 381314-3553, Iran;4. Laboratory of Theoretical and Computational Biophysics, Ton Duc Thang University, Ho Chi Minh City, Viet Nam;5. Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Viet Nam;1. Obstetrics and Gynecology Hospital, NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), School of Life Sciences, Fudan University, Shanghai, 200011, China;2. Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211116, China;3. Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, 200011, China;4. Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China;5. Anhui Province Key Laboratory of Reproductive Health and Genetics, Anhui Medical University, Hefei, 230022, China;6. Anhui Provincial Engineering Technology Research Center for Biopreservation and Artificial Organs, Hefei, 230022, China;7. Clinical Center of Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China;8. Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, 215002, China;1. Institut National de la Recherche Scientifique, Centre-Énergie, Matériaux et Télécommunications, 1650 Blvd. Lionel-Boulet, Varennes, QC, J3X-1S2, Canada;2. Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama, 700-8530, Japan;3. Institut National de la Recherche Scientifique, Centre-Eau, Terre et Environnement, 490 Rue de la Couronne, Quebec, QC, G1K-9A9, Canada;4. Department of Mechanical Engineering, Université de Sherbrooke, Sherbrooke, QC, J1K 2R1, Canada;1. School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest-Ansermet 30, CH-1211 Geneva, Switzerland;2. ESBATech – A Novartis Company, Wagistrasse 21, CH-8952 Zürich-Schlieren, Switzerland |
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| Abstract: | Structural differences in melanins were studied by Curie-point pyrolysis-gas chromatography-mass spectrometry, electron spin resonance spectroscopy and chloroquine binding. Pyrolysis-gas chromatographic data on the polymer allow the calculation of a UU index that expresses the relative amount of unindolized DOPA-derived units in the melanins.It is shown that the content of unindolized units in the polymer depends strongly on the oxidation time and DOPA concentration used during the melanin synthesis. Comparison of the chloroquine binding to melanins and the pyrolysis data showed that there is an inverse relationship between the affinity of chloroquine and the UU index. |
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