| 6α-取代的(1S, 7aS)-(+)-1-叔丁氧基-7a-甲基-2, 3, 5, 6, 7, 7a-六氢茚-5- 酮的合成 |
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| 引用本文： | 孙琳,熊意风,伍建华,蔡祖恽.6α-取代的(1S, 7aS)-(+)-1-叔丁氧基-7a-甲基-2, 3, 5, 6, 7, 7a-六氢茚-5- 酮的合成[J].化学学报,1991,49(4):406-411. |
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| 作者姓名： | 孙琳 熊意风 伍建华 蔡祖恽 |
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| 作者单位： | 中国科学院上海有机化学研究所.上海(200032) |
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| 摘 要： | 用化学动力学控制的方法在化合物3的5-C上C=O与6-C发生烯醇化生成锂盐,然后可在6-C位分别引入甲基、烯丙基、苄基、溴以及羟基取代基。产物6、7、8、9a和11经鉴定,除9α外其他都是α和β构型的混合物,其中以α-构型取代物为主。
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| 关 键 词： | 甾体 化学动力学控制 合成 激素 甲基 烯丙基 苄基 溴 羟基 丁氧基 |
Synthesis of 6α-substituted (1S, 7aS)-(+)-1-t-butoxy-7a-methyl-2, 3, 5, 6, 7, 7a-hexahydroinden-5-ones |
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| Institution: | Shanghai Inst Organ Chem., CAS.Shanghai(200032) |
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| Abstract: | It is known that 11-C-substituted steroids usually possess much higher biological activities than their mother substances. In this paper six 6α-substituted (1S, 7aS)-(+)-1-t-butoxy-7a-methyl-2, 3, 5, 6, 7, 7a-hexahydroinden-5-ones (4, 6, 7, 8, 9, 11) were synthesized in good yields with high stereoselectivity. These compounds are good intermediates for the syntheses of the related 11-C-substituted steroids. |
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| Keywords: | SYNTHESIS HORMONE METHYL GROUP ALLYL GROUP BENZYL GROUP BROMINE HYDROXY GROUP BUTOXY GROUP TERT-BUTYL GROUP SUBSTITUENT GROUP |
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