An efficient and chemoselective Brønsted acidic ionic liquid-catalyzed N-Boc protection of amines |
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Authors: | Sadula Sunitha |
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Institution: | Lipid Science and Technology Division, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500 007, India |
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Abstract: | The first report of a Brønsted acidic ionic liquid, 1-methylimidazolium tetrafluoroborate (HMIm)BF4], catalyzed efficient and chemoselective N-Boc protection of various amines using (Boc)2O is presented. Optically pure amino alcohols and amino acid esters were converted efficiently to their corresponding optically pure N-Boc derivatives. The reported method is mild, solvent-free and has the advantages of both homogeneous and heterogeneous catalysis with high product yields, selectivity and ease of product separation. |
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Keywords: | Amines Brø nsted acidic ionic liquid Chiral aminols Chiral amino acid esters Di-tert-butyl pyrocarbonate N-Boc protection |
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