First heterogeneously palladium-catalysed fully selective C3-arylation of free NH-indoles |
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| Authors: | Giuseppe Cusati |
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| Institution: | IRCELYON-Institut de recherches sur la catalyse et l’environnement de Lyon, UMR 5256 CNRS-Université Claude Bernard Lyon 1, 2 Avenue Albert Einstein, F-69626 Villeurbanne, France |
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| Abstract: | A simple heterogeneously palladium-catalysed procedure for the selective C3-arylation of indoles is reported. Under relatively standard reaction conditions (Pd-catalyst, K2CO3, dioxane, reflux), using only 1 mol % Pd(NH3)4]/NaY as the catalyst, indoles substituted or not at position 2 gave up to 92% conversion (i.e., 85% isolated yield) towards the expected C3-arylated indole. |
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| Keywords: | Indoles Selective C3-arylation Palladium Heterogeneous catalysis |
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