Engineered self-healing single-cavity microcapsules for pulsatile release of drug delivery |
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Institution: | 1. State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China;2. School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, 100049, China;3. Division of Molecular Science, Graduate School of Science and Technology, Gunma University, 1-5-1, Tenjin-cho, Kiryu, 376-8515, Japan;4. Innovation Academy for Green Manufacture, Chinese Academy of Sciences, Beijing, 100190, China |
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Abstract: | A wide range of polymer-based drug delivery systems have been reported for the treatment of various diseases. However, the dosing regimen of many drugs, such as stimulator of interferon genes agonists, programmed cell death protein-1 antibodies, and coronavirus disease 2019 vaccines, consists of repeated intratumoral or intramuscular injections. These repeated administrations may lead to poor adherence, thus resulting in compromised therapeutic outcomes and increased financial burden. Here, we developed a multidose drug delivery platform by engineering polylactic-co-glycolic acid (PLGA) with different molecular weights into self-healing single-cavity microcapsules (SSM). This approach showed a flexible collocation strategy to achieve customized pulsatile drug release and was fully degradable with good safety. Notably, this single-injection delivery system contains only PLGA, holding great promise for clinical translation. |
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Keywords: | Drug delivery Single-cavity microcapsule Pulsatile release Self-healing microparticle |
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