Trimethoprim-selective electrodes with molecularly imprinted polymers acting as ionophores and potentiometric transduction on graphite solid-contact |
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Authors: | Tâ nia S.C.R. Rebelo,J. Rafaela L. Guerreiro |
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Affiliation: | a REQUIMTE/ISEP, Instituto Superior de Engenharia do Porto, Porto, Portugalb INSA-Porto, Instituto Nacional de Saúde Dr. Ricardo Jorge, Porto, Portugalc REQUIMTE/Serviço de Química-Física, Faculdade de Farmácia da Universidade do Porto, Portugal |
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Abstract: | This work proposes a new biomimetic sensor material for trimethoprim. It is prepared by means of radical polymerization, having trimethylolpropane trimethacrylate as cross-linker, benzoyl peroxide as radicalar iniciator, chloroform as porogenic solvent, and methacrylic acid and 2-vinyl pyridine as monomers. Different percentages of sensor in a range between 1 and 6% were studied. Their behavior was compared to that obtained with ion-exchanger quaternary ammonium salt (additive tetrakis(p-chlorophenyl)borate or tetraphenylborate). The effect of an anionic additive in the sensing membrane was also tested.Trimethoprim sensors with 1% of imprinted particles from methacrylic acid monomers showed the best response in terms of slope (59.7 mV/decade) and detection limit (4.01 × 10− 7 mol/L). These electrodes displayed also a good selectivity towards nickel, manganese aluminium, ammonium, lead, potassium, sodium, iron, chromium, sulfadiazine, alanine, cysteine, tryptophan, valine and glycine. The sensors were not affected by pH changes from 2 to 6. They were successfully applied to the analysis of water from aquaculture. |
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Keywords: | Trimethoprim Potentiometry Ion selective sensors Molecularly imprinted polymers Aquaculture water |
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