2-(Adamantan-1-yl)imidazo[1,2-<Emphasis Type="Italic">a</Emphasis>]pyridines and Their Derivatives |
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Authors: | R I Yurchenko A D Ponomarenko N N Svarovskaya A A Tolmachev |
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Institution: | (1) National Technical University of Ukraine, Kiev, 03056, Ukraine |
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Abstract: | A series of 1-adamantylimidazo1,2-a]pyridines has been synthesized. The negative influence of electron-acceptor substituents in the pyridine ring on the alkylation of substituted 2-aminopyridines with bromomethyl (adamantan-1-yl) ketone has been demonstrated. Bromination of adamantylimidazo-1,2-a]pyridines on boiling in liquid bromine or in the presence of a Lewis acid resulted in insertion of a bromine atom in the imidazole ring without affecting the adamantane nucleus. The compounds studied take part in the Ritter reaction despite the absence of an easily removed groups in the adamantane nucleus.__________Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, 761–766, May, 2005. |
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Keywords: | 2-(adamantan-1-yl)imidazo[1 2-a]pyridines bromination nitrosation the Ritter reaction |
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