Solvent‐Free Microwave‐Assisted Synthesis of Novel 4‐Hetarylpyrazolo[1,5‐a][1,3,5]triazines |
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| Authors: | Henry Insuasty Sandra Estrada Jairo Quiroga Braulio Insuasty Rodrigo Abonia Manuel Nogueras Justo Cobo |
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| Institution: | 1. Heterocyclic Compounds Research Group, Department of Chemistry, Universidad de Nari?o, , Pasto, Colombia;2. Heterocyclic Compounds Research Group, Department of Chemistry, Universidad del Valle, , Cali, Colombia;3. Department of Inorganic and Organic Chemistry, Universidad de Jaén, , 23071 Jaén, Spain |
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| Abstract: | A series of novel 4‐hetaryl substituted pyrazolo1,5‐a]1,3,5]triazines were synthesized by microwave assisted reaction between O,S‐diethyl hetaroylimidothiocarbonates and 5‐amino‐3‐aryl‐1H‐pyrazoles under solvent‐free conditions. This procedure led to the formation of mixtures of two new pyrazolotriazine derivatives in a 1:4 ratio, which were separated by column chromatography being their corresponding structures unambiguously established by spectroscopic and analytical techniques. Comparison of the reactions mediated by microwave irradiation and by conventional heating in solution of DMF showed that both procedures afforded the same mixtures of products, but the first approach required shorter reaction times and gave higher yields than the second one. |
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