Zwitterionic Salts from the Reaction of Symmetrical and Unsymmetrical (thio)Barbituric Acids with 2‐Pyridinecarbaldehyde under Solvent‐free Condition |
| |
Authors: | Nader Noroozi Pesyan Yaser Hosseini Alireza Shokr Ertan Şahin |
| |
Affiliation: | 1. Department of Chemistry, Faculty of Science, Urmia University, 57159, Urmia, Iran;2. Department of Chemistry, Faculty of Science, Atatürk University, 25240, Erzurum, Turkey |
| |
Abstract: | A simple and efficient synthesis for the preparation of unusual charge‐separated pyridinium (thio)barbiturate zwitterion derivatives was achieved via a one‐pot reaction of (thio)barbituric acid derivatives and 2‐pyridinecarbaldehyde under solvent‐free condition and also in methanol under refluxing. The structure of the compounds was confirmed by 1H NMR, 13C NMR, FT‐IR, mass and X‐ray analysis. The mechanism of the formation is discussed. Instead, no related pyridinium zwitterion was afforded from the reaction between dimedone and 2‐pyridinecarbaldehyde under the same conditions and its xanthene derivative was obtained. |
| |
Keywords: | Barbituric acid Pyridinium salt Zwitterionic salt Solvent‐free |
|
|