Polycyclic N‐Heterocyclic Compounds,Part 71: Synthesis and Bronchodilator Evaluation of 5‐Substituted 1,2‐Dihydrofuro[3,2‐f][1,7]naphthyridines and Related Compounds |
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| Authors: | Kensuke Okuda Tetsuo Matsushita Takashi Hirota Kenji Sasaki |
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| Affiliation: | 1. Laboratory of Medicinal and Pharmaceutical Chemistry, Gifu Pharmaceutical University, , Gifu, 501‐1196 Japan;2. Faculty of Pharmaceutical Sciences, Okayama University, , Okayama, 700‐8530 Japan |
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| Abstract: | Several 5‐substituted 1,2‐dihydrofuro[3,2‐f][1,7]naphthyridines were synthesized as part of our research to develop new effective bronchodilators. Amines, sulfanyls, and alcohols were used as substituents at the fifth position. Tetracyclic compounds were also obtained. Evaluation of the effects of the newly synthesized compounds on carbamoylcholine chloride‐induced contractions of trachea revealed one promising bronchodilator candidate with potency comparable to that of 3‐isobutyl‐1‐methylxanthine. |
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