Pyrazinium Di(hydrogen sulfate) as a Novel,Highly Efficient and Homogeneous Catalyst for the Condensation of Enolizable Ketones with Aldehydes,Acetonitrile and Acetyl Chloride |
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Authors: | Ardeshir Khazaei Mohammad Ali Zolfigol Mohammad Mokhlesi Abdolkarim Zare Fatemeh Derakhshan‐Panah Maria Merajoddin Hassan Keypour Ahmad Ali Dehghani‐Firouzabadi |
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Affiliation: | 1. Faculty of Chemistry, Bu‐Ali Sina University, Hamedan, 6517838683, Iran;2. Chemistry Department, Payame Noor University, 19395‐4697 Tehran, I.R. of Iran;3. Department of Chemistry, Yazd University, Yazd 89195741, Iran |
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Abstract: | A highly efficient protocol for the synthesis of β‐acetamido ketone or ester derivatives in the presence of pyrazinium di(hydrogen sulfate) {Py(OSO3H)2} as a novel, green and homogeneous solid acid catalyst at room temperature is described. One‐pot multi‐component condensation of enolizable ketones or alkyl acetoacetates with aldehydes, acetonitrile and acetyl chloride affords the title compounds in high to excellent yields and in relatively short reaction times. In this work, the efficiency of our recently reported solid acid catalyst, saccharin sulfonic acid (Sa‐SO3H), in the synthesis of β‐acetamido ketones/esters is also studied. Moreover, in this research, some new β‐acetamido ketones and esters (i.e. one complex structure) are prepared. |
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Keywords: | Pyrazinium di(hydrogen sulfate) {Py(OSO3H)2} Saccharin sulfonic acid (Sa‐SO3H) Enolizable ketone β ‐Acetamido ketone β ‐Acetamido ester Solid acid |
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