Synthesis of Novel Spiro Thiazolotriazole Derivatives via 1,3‐Dipolar Cycloaddition of Azomethine Ylide |
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| Authors: | Li Xiaofang Liu Bin Liu Haochong Yu Xianyong Yi Pinggui |
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| Institution: | 1. Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, Hunan Province College Key Laboratory of QSAR/QSPR;2. School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, , Hunan 411201, China |
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| Abstract: | The 1,3‐dipolar cycloaddition of azomethine ylide generated in situ from isatin and sarcosine to 5‐arylmethylidene thiazolo3,2‐b]1,2,4]triazol‐6(5H)‐ones afforded novel 1′‐methyl‐4′‐aryldispiroindole‐3,2′‐pyrrolidine‐3′,5″‐1,3]thiazolo3,2‐b]1,2,4]triazole]‐2,6″ (1H)‐diones in moderate yields. The structures of all the products were characterized thoroughly by NMR, infrared spectroscopy (IR), mass spectroscopy (MS) elemental analysis together with X‐ray crystallographic analysis. |
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