A Facile Synthesis of Novel Dihydroindeno[1,2‐e][1,2,4]triazolo[3,4‐b][1,3,4]thiadiazines Using HTIB |
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| Authors: | Om Prakash Deepak Kumar Aneja Deepak Wadhwa Ravi Kumar Sanjiv Arora |
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| Institution: | 1. Institute of Pharmaceutical Sciences, Kurukshetra University, , Kurukshetra, 136119 Haryana, India;2. Department of Chemistry, Kurukshetra University, , Kurukshetra, 136119 Haryana, India;3. Department of Chemistry, Dyal Singh College, , Karnal, Haryana, India |
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| Abstract: | The synthesis of a series of 21 novel 3‐alkyl/aryl‐7/9‐methyl‐10,10a‐dihydroindeno1,2‐e]1,2,4]triazolo3,4‐b]1,3,4]thiadiazines ( 4 ) has been achieved by the cyclocondensation between 4/6‐methyl‐2‐tosyloxy‐1‐indanones ( 2 ) and 3‐alkyl/aryl‐4‐amino‐5‐mercapto‐1,2,4‐s‐triazoles ( 3 ). 4/6‐Methyl‐2‐tosyloxy‐1‐indanones ( 2 ) were readily accessible through hypervalent iodine oxidation of 4/6‐methyl‐1‐indanones using (hydroxy)tosyloxyiodo]benzene (HTIB, Koser's reagent) in acetonitrile. |
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