Synthesis of Novel 5,6‐Dihydropyrrolo[2,1‐a]isoquinolines via Grob Reaction between (E)‐1,1,1‐Trifluoro‐3‐nitro‐2‐butene and 3,4‐Dihydroisoquinolines |
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| Authors: | Vladislav Y Korotaev Vyacheslav Y Sosnovskikh Alexey Y Barkov Pavel A Slepukhin Yurii V Shklyaev |
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| Institution: | 1. Department of Chemistry, Ural State University, Ekaterinburg 620083, Russia;2. Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620041, Russia;3. Institute of Technical Chemistry, Ural Branch of the Russian Academy of Sciences, Perm 614600, Russia |
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| Abstract: | Uncatalyzed cycloaddition of 3,4‐dihydroisoquinolines to (E)‐1,1,1‐trifluoro‐3‐nitro‐2‐butene via Grob reaction provide a simple one‐step route to the 5,6‐dihydropyrrolo2,1‐a]isoquinolines, which represent the basic structural framework of the antitumor active alkaloid crispine. |
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