Pyrazolones as Building Blocks in Heterocyclic Synthesis: Synthesis of New Pyrazolopyran,Pyrazolopyridazine and Pyrazole Derivatives of Expected Antifungicidal Activity |
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| Authors: | Mahmoud. M. M. Ramiz Ibrahim. S. Abdel Hafiz Mohamed. A. M. Abdel Reheim Hatem M. Gaber |
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| Affiliation: | 1. Faculty of Electronic Engineering, Minufiya University, Menouf, Egypt;2. Department of Chemistry, Faculty of Education, Suez Canal University, Arish, Egypt;3. National Organization for Drug Control and Research (NODCAR), P.O. Box 29, Cairo, Egypt |
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| Abstract: | A series of new pyrazolone and pyrazole derivatives with expected antifungicidal activity have been prepared through the reactions 3‐phenyl‐1‐H‐pyrazol‐5(4H)‐one ( 3 ) and 4‐(dimethylaminomethylene)‐3‐phenyl‐1H‐pyrazol‐5(4H)‐one ( 5 ) with a variety of electrophilic reagents and nucleophilic reagents. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR and mass spectral studies. |
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| Keywords: | Pyrazolone Pyrazolopyran and pyrazolopyridazine and pyrazole derivatives |
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