Synthesis and Insecticidal Activities of Chlorothiazolyl Analogs of Nitromethylene Neonicotinoids with Tetrahydropyridine Fixed cis‐Configuration |
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| Authors: | Xusheng Shao Xinglong Huang Qian Shi Zhong Li Liming Tao Gonghua Song |
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| Institution: | Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, , Shanghai, 200237 China |
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| Abstract: | The chlorothiazolyl moiety was an effective bioisoster of chloropyridyl in pesticide molecular design. Replacement of chloropyridyl in cis‐nitromethylene neonicotinoids with chlorothiazolyl generated the chlorothiazolyl counterpart of nitromethylene neonicotinoids with tetrahydropyridine fixed cis‐configuration. Bioassay against cowpea aphis (Aphis craccivora) indicated that the chlorothiazolyl analogs could maintain the high insecticidal activity. |
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