Synthesis and Biological Evaluation of Laxiflorin J Derivatives as Potential Antitumor Agents |
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| Authors: | Jing‐Ping Liu Hong‐Bin Zhang Sheng‐Xiong Huang Jian‐Xin Pu Wei‐Lie Xiao Xue‐Ping Zhang Wen‐Ding Xiao Chun Lei Han‐Dong Sun |
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| Affiliation: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, , Kunming, 650204 People's Republic of China;2. Department of Chemistry, Yunnan Normal University, , Kunming, 650092 People's Republic of China;3. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, , Kunming, 650091 People's Republic of China |
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| Abstract: | Laxiflorin J, isolated from the leaves of Isodon eriocalyx var. laxiflora, showed significant inhibitory activity toward T‐24 cells. A series of laxiflorin J derivatives were synthesized and their in vitro activity was evaluated against BEL‐7402, A‐549, HT‐29, HL‐60, MOLT‐4 tumor cell lines, with IC50 values ranging from 1.3 to 42.2 μg mL?1. |
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