Facile Synthesis of 3,6‐Disubstituted‐1,2,4‐triazolo‐[3,4‐b]‐1,3,4‐thiadiazoles via Oxidative Cyclization of n‐Heteroaryl‐Substituted Hydrazones and Their Biological Activity

Fused 3,6‐disubstituted triazolothiadiazoles were synthesized in good yield from a rapid and convenient oxidative cyclization of N‐heteroaryl‐substituted hydrazones promoted by chloramine‐T trihydrate at ambient temperature. The structure of the synthesized compounds was confirmed by FTIR, ¹H NMR, ¹³C NMR, and mass spectral data. The synthesized compounds were evaluated for their antioxidant and antitubercular activities. All the compounds 5a‐i and 6a‐i showed good antitubercular activity. However, only compounds 5a‐i showed good antioxidant activity.