Solvent‐Free Synthesis of 2‐(Phenylamino)‐4‐(trifluoromethyl)‐1,6‐dihydropyrimidine Derivatives Catalyzed by Sulfamic Acid |
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| Authors: | Shide Shen Weihua Yang Chenxia Yu Tuanjie Li Changsheng Yao |
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| Affiliation: | 1. Xuzhou Institute of Architectural Technology, , Xuzhou, Jiangsu, 221116 People's Republic of China;2. School of Chemistry and Chemical Engineering, Xuzhou Normal University, Key Laboratory of Biotechnology on Medical Plant, , Xuzhou, Jiangsu, 221116 People's Republic of China |
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| Abstract: | A series of 2‐(phenylamino)‐4‐(trifluoromethyl)‐1,6‐dihydropyrimidine derivatives were synthesized efficienly via the reaction of aryl aldehyde, ethyl 4,4,4‐trifluoro‐3‐oxobutanoate and 1‐phenylguanidine carbonate catalyzed by sulfamic acid under solvent‐free conditions. This protocol has the advantages of mild condition, high yields and environmentally benign procedure. |
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