An Efficient Synthesis of New 5‐(1‐Aryl‐1H‐pyrazole‐4‐yl)‐1H‐tetrazoles from 1‐Aryl‐1H‐pyrazole‐4‐carbonitriles via [3 + 2] Cycloaddition Reaction |
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| Authors: | Maurício S. dos Santos Alice M. R. Bernardino Luiz C. S. Pinheiro Marilene M. Canto‐Cavalheiro Leonor L. Leon |
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| Affiliation: | 1. Universidade Federal de Itajubá, Instituto de Ciências Exatas, Departamento de Física e Química, , 37500‐903 Itajubá, MG, Brazil;2. Universidade Federal Fluminense, Instituto de Química, Departamento de Química Organica, Programa de Pós‐Gradua??o em Química, , 24210‐150 Niterói, RJ, Brazil;3. Funda??o Oswaldo Cruz, Laboratório de Bioquímica de Tripanosomatídeos, , 21040‐900 Rio de Janeiro, RJ, Brazil |
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| Abstract: | A series of new 5‐(1‐aryl‐1H‐pyrazole‐4‐yl)‐1H‐tetrazoles 4a‐l were synthesized via [3 + 2] cycloaddition reaction from 1‐aryl‐1H‐pyrazole‐4‐carbonitriles 3a‐l , sodium azide and ammonium chloride, using dimethylformamide (DMF) as solvent, in good yields: 64–85%. The structures of these newly synthesized compounds were determined from the IR, 1H‐ and 13C‐NMR spectroscopic data and elemental analyses. |
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