反相高效液相色谱法测定化妆品中的防晒剂

用反相高效液相色谱法在２０ｍｉｎ内同时测定化妆品中１１种防晒剂。色谱柱为ＹＷＧ－Ｃ１８柱，流动相为甲醇－四氢呋喃－水－高氯酸（２００２００１６００．１，Ｖ／Ｖ），检测波长为３１１ｎｍ。报告了对１０３种防晒化妆品测定的结果。

Determination of Sunscreen Agents in Cosmetic Products by Reversed Phase High Performance Liquid Chromatography

A method for quantitative determination of eleven sunscreen agents (benzophenone-4,p-amino-benzoic acid, salicylic acid, benzophenone-3,phenyl salicylate, 4-methylbenzylidene camphor, octyl dimethyl p-amino-benzoate, isopropyl dibenzoylmethane, butyl methoxydibenzoylmethane, octyl methoxycinnamate, octyl salicylate) in cosmetic products is described. It was based on a high performance liquid chromatographic separation under the condition of isocratic elution with a mixture solution of methanol-THF-water-70% perchloric acid (200:200:160:0.1) by using a column packed with 10 microns YWG-C15 and UV detection. The recoveries (n = 6) were 94.1%-101% and the relative standard deviations(n = 6) for all eleven sunscreen agents were less than 5%. In addition, the results of analysis of 30 samples out of 103 samples of commercial suntan cosmetics performed are reported in this paper.