乙交酯/丙交酯/己内酯三元共聚物的合成及表征

生物降解性高分子具有在生理条件下可以自行降解、最终被降解为单体或成为二氧化碳和水，从而或被机体吸收、或通过代谢途径排出体外的特性，已被广泛用作药物释放体系的载体、手术缝合线、外科手术及组织修复材料等各个方面，是当前生物医用高分子的一个重要分支．脂肪族聚酯由于具有良好生物相容性而成为最引人注意和有发展前途的一类生物降解性高分子，其中聚乙交酯（ＰＧＡ）、聚丙交酯（ＰＬＡ）及丙交酯／乙交酯共聚物（ＰＬＧＡ）是这一类聚酯中应用最为广泛的几种．Ｍｉｌｌｅｒ等［１］研究发现乙交酯（ＧＡ）和丙交酯（ＬＡ）共聚…

SYNTHESIS AND CHARACTERIZATION OF GLYCOLIDE/ LACTIDE/CAPROLACTONE TRI\|COMPONENT COPOLYMER

A series of tri\|component copolyesters composed of glycolide/lactide/caprolactone (PGLC) were obtained by bulk ring\|opening copolymerization of glycolide(GA),L\|lactide (L\|LA) and caprolactone(CL) with Sn(Oct)\-2 as catalyst for the purpose of biomedical applications.Structure of the PGLC copolyester was characterized by means of GPC,\{\}\+1H\|NMR,DSC and X\|ray diffractometry techniques.It was found that the obtained polymer was a pure copolymer that consisting of no other side\|produced polymers and the copolyester was a random copolymer that presented an amorphous structure in a large range of composition.The hydrophilicity and degradation rate of the copolyester were also studied in detail and it was found that the hydrophilicity and hydrolysis rate were improved by increasing the amount of GA.The mechanical properties of the PGLC copolyester were identified by measuring the tensile strength and the elongation at break.The elongation of the copolyester could be improved by introducing CL to the PLGA.That the PGLC copolyester was a potential biomedical material was suggested.