| 甾体植物生长激素合成的研究V: 甾体醛与3-甲基丁烯-2-内酯醛醇反应的立体化学 |
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| 引用本文： | 周维善,田伟生,郑虎,赵旭阳. 甾体植物生长激素合成的研究V: 甾体醛与3-甲基丁烯-2-内酯醛醇反应的立体化学[J]. 化学学报, 1988, 46(6): 598-603 |
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| 作者姓名： | 周维善 田伟生 郑虎 赵旭阳 |
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| 作者单位： | 中国科学院上海有机化学研究所;华西医科大学药学院 |
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| 摘 要： | 研究了甾体醛与3-甲基丁烯-2-内酯的醇醛缩合反应的温度与产物的立体化学的关系. 这一反应是合成油菜甾醇内酯植物生长激素边链的关键. 结果发现-78℃是这一醇醛缩合反应的最佳反应温度.
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| 关 键 词： | 内酯 植物激素 甾族化合物 质子磁共振谱法 立体化学 醛 构型 植物生长调节物质 油菜甾醇内酯 甲基丁烯酸P |
Studies on steroidal plant-growth hormones V: Spectrochemistry of aldol reaction of steroidal aldehyde with 3-methylbut-2-enolide anion |
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| ZHOU WEISHAN,TIAN WEISHENG,ZHENG HU,ZHAO XUYANG. Studies on steroidal plant-growth hormones V: Spectrochemistry of aldol reaction of steroidal aldehyde with 3-methylbut-2-enolide anion[J]. Acta Chimica Sinica, 1988, 46(6): 598-603 |
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| Authors: | ZHOU WEISHAN TIAN WEISHENG ZHENG HU ZHAO XUYANG |
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| Abstract: | The relation between stereochem. of products and temperature in the aldol reaction of the steroidal aldehyde I with the 3-methylbut-2-enolide anion has been studied. The most suitable reaction temperature (-78? has been found in this aldol reaction to give the major product, (22R,23R)-II, which is the key intermediate for the synthesis of the side chain of brassinolide and its analogs. |
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| Keywords: | LACTONES PHYTOHORMONE STEROIDS PROTON MAGNETIC RESONANCE SPECTROMETRY STEREOCHEMISTRY ALDEHYDES CONFIGURATION PLANT GROWTH REGULATING SUBSTANCE BRASSINOLIDE METHYLBUTENOIC ACID P |
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