Synthesis of 6-substituted-4-hydroxy-2-pyridinones via intramolecular ketene trapping of functionalized enamine-dioxinones |
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| Authors: | Patel Bhavesh H Mason Andrew M Barrett Anthony G M |
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| Affiliation: | Department of Chemistry, Imperial College, London SW7 2AZ, UK. |
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| Abstract: | The synthesis of various 6-substituted-4-hydroxy-2-pyridinones is reported. The functionalized keto-dioxinones were constructed via a diethylzinc mediated crossed Claisen condensation reaction and subsequent enamine formation, thermolysis, and cyclization-aromatization providing the pyridinone unit. |
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