New polyhydroxylated furostanol saponins with inhibitory action against NO production from Tupistra chinensis rhizomes |
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| Authors: | Xu Lan-Lan Zou Kun Wang Jun-Zhi Wu Jun Zhou Yuan Dan Fei-Jun Yang Jing |
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| Institution: | Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, PR China. llxu@ctgu.edu.cn |
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| Abstract: | Two furostanol saponins were obtained from the rhizomes of Tupistra chinensis Bak. Their structures were determined as 5beta-furost-delta(25(27))-en-1beta,2beta,3beta,4beta,5beta,7alpha,22xi,26-octaol-6-one-26-O-beta-D-glucopyranoside (1) and 5beta-furost-delta(25(27))-en-1beta,2beta,3beta,4beta,5beta,6beta,7alpha,22xi,26-nonaol-26-O-beta-D-glucopyranoside (2), on the basis of chemical and spectroscopic evidence. Both compounds displayed marked inhibitory action against NO production in rat abdomen macrophages induced by lipopolysaccharide (LPS) at 40 microg/mL. |
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