Dynamics of peptidergic secretory granule transport are regulated by neuronal stimulation |
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| Authors: | Jacqueline A Sobota William A Mohler Ann E Cowan Betty A Eipper and Richard E Mains |
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| Institution: | (1) Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Ave, 06030-3401 Farmington, CT, USA;(2) Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Ave, 06030 Farmington, CT, USA;(3) Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, 263 Farmington Ave, 06030 Farmington, CT, USA;(4) Center for Cell Analysis and Modeling, University of Connecticut Health Center, 263 Farmington Ave, 06030 Farmington, CT, USA |
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| Abstract: | Background Peptidergic neurons store and secrete the contents of large dense core vesicles (LDCVs) from axon terminals and from dendrites.
Secretion of peptides requires a highly regulated exocytotic mechanism, plus coordinated synthesis and transport of LDCVs
to their sites of release. Although these trafficking events are critical to function, little is known regarding the dynamic
behavior of LDCVs and the mechanisms by which their transport is regulated. Sensory neurons also package opiate receptors
in peptide-containing LDCVs, which is thought to be important in pain sensation. Since peptide granules cannot be refilled
locally after their contents are secreted, it is particularly important to understand how neurons support regulated release
of peptides. |
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