液液分散微萃取/GC-MS法测定婴幼儿一次性用品中5种致敏原物质

建立了同时测定婴幼儿一次性用品中5种致敏原物质(柠檬烯、沉香醇、柠檬醛、乙酸苄酯和肉桂醛)的分散液液微萃取/气相色谱-质谱(DLLME/GC-MS)检测方法。样品经乙腈浸泡提取、水分散和盐析后用四氯化碳萃取浓缩,采用GC-MS测定,外标法定量。目标物在0.01~10 mg/kg范围内线性关系良好,相关系数在0.99以上。方法检出限为0.01~0.1 mg/kg。加标回收率为78.7%~106%,相对标准偏差为2.4%~11.3%。该方法前处理简单,灵敏度高,可满足纸尿裤、婴儿专用湿巾等一次性婴幼儿用品中5种致敏原物质的检测要求。

Determination of 5 Allergens in Disposable Product for Infants by Liquid-Liquid Micro-extraction Combined with GC-MS

A new method was developed for the determination of 5 allergens(cinene,linalool,citral,benzyl acetate,cinnamaldehyde) in disposable product for infants by liquid-liquid micro-extraction combined with GC-MS.Samples were extracted with acetonitrile.The extract was dispersed with water,salted out with NaCl,and concentrated with tetrachloromethane(CCl4).The analytes were detected by GC-MS with the external standard method.The calibration curves were linear in the range of 0.01-10 mg/kg,wtih correlation coefficients more than 0.99.The detection limits were in the range of 0.01-0.1 mg/kg.The spiked recoveries were in the range of 78.7%-106%,with RSDs of 2.4%-11.3%.The result comfirmed that the method was accurate,rapid and sensitive,and was suitable for the determination of 5 allergens in disposable product for infants.