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Laser-Induced Fluorescence Bronchoscopy for Detection and Localization of Early Lung Cancer |
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| Authors: | XIE Shusen LI Buhong LI Hui ZHENG Wei LU Zukang |
| Institution: | 1. Biomedical Optical Lab, Institute of Laser,Fujian Teachers University,;National Research Center of Optical Instrument Engineering,Zhejiang University, 2. Biomedical Optical Lab, Institute of Laser,Fujian Teachers University, 3. Biomedical Optical Lab, Institute of Laser,Fujian Teachers University,;Biomedical Engineering Research Center,Nanyang Technological University,Singapore 4. National Research Center of Optical Instrument Engineering,Zhejiang University, |
| Abstract: | Experimenatal results on the development of a Laser-Induced Fluorescence Bronchoscopy(LIFB) for the detection and localization of early lung cancer are reported in this paper. The system utilizes fluorescence of photosensitizer drug to provide real time video imaging for the examined lung tissue. Color filters are used to differentiate signal from background and a computer image processing technique is also applied to subtract the background. Moreover, a pseudocolor contrast enhancement method was developed to enhance the fluorescence image displayed on the vidio monitor. Suspicious areas are identified by pseudocolor image to guide biopsy, and several clinical trials show that sensitivity and contrast capability of the system should permit the detection and localization of early lung cancer. |
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