| Abstract: | A total synthesis of hystrine has been realised with good yield by the introduction of a double link into the piperidine nucleus of synthetic ammodendrine, followed by deacetylation, and purification with the aid of the nitroso derivative. The identity of the synthetic product with authentic hystrine was established by its chromatographic behaviour, by UV.-, IR.- and mass spectra as well as by the properties of its nitroso derivative. Thus the proposed structure of hystrine as 3-(2, 3, 4, 5-tetrahydropyrid-6-yl)-1, 4, 5, 6-tetrahydropyridine (V) is proved. |
