| An Efficient Method for α-Alkylation of γ-Butyrolactone |
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| 作者姓名： | Yuan Ru MENG Ye Di GUAN |
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| 作者单位： | Yuan Ru MENG，Ye Di GUAN Department of Chemistry，Peking University，Beijing 100871 State Key Laboratory of Elemento-Organic Chemistry，Nankai University，Tianjin 300071 |
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| 摘 要： | Alkylated lactone is a common structure and segment in many natural products and medicines. The examples of alkylating lactone system at -position, obtained by reaction with alkyl halide such as MeI, in the presence of strong base LDA or it抯 derivatives, are very few1a, 1b. When this method was applied to the aromatic compound, the self-condensation of g-butyrolactone could not be avoided. In our previous work we have reported the hydrogenation of ? -unsaturated carbonyl compounds by cat…
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| 关 键 词： | α-Alkylation of γ-butyrolactone |
An Efficient Method for α-Alkylation of γ-Butyrolactone |
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| Yuan Ru MENG,Ye Di GUAN.An Efficient Method for α-Alkylation of γ-Butyrolactone[J].Chinese Chemical Letters,2002,13(11). |
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| Authors: | Yuan Ru MENG Ye Di GUAN |
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| Abstract: | This paper provides a simple, convenient and mild condition method for -alkylation of g-butyrolactone. Three types of (E)-a-alkenyl-g-butyrolactone compounds were synthesized by condensation of corresponding aldehydes and g-butyrolactone, using MeONa and EtONa as base. Then the a-alkyl-g-butyrolactones were gained by reducing the former alkenyl compounds through catalytic transfer hydrogenation under Pd/C catalyst with sodium hypophosphite at room temperature. |
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| Keywords: | Alkylation of -butyrolactone condensation catalytic transfer hydrogenation Pd / C-sodium hypophosphite |
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