Anodic hydroxylation of 1-carbomethoxy-1,2,3,4-tetrahydrocarbazoles |
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Authors: | James F Rusling Barry J Scheer Azita Owlia Thomas T-t Chou James M Bobbitt |
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Institution: | Department of Chemistry (U-60), University of Connecticut, Storrs, CT 06268, U.S.A. |
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Abstract: | 1-Carbomethoxy-1,2,3,4-tetrahydrocarbazole (1) and its 7-methoxy derivative (2) were oxidized at carbon felt anodes in acetonitrile containing 0.2 M LiClO4 and 2-17 M water at potentials on the rising portion of the primary oxidation peak to yield products formed by formal substitution of the C-1 H atom with hydroxide. The resulting 1-hydroxy-l-carbomethoxy-1,2,3,4-tetrahydrocarbazole and its 7-methoxy derivative were isolated in 44 and 22% yields, respectively, when sodium bicarbonate was used to control acidity of the medium. Structures were elucidated by NMR, IR, elemental analysis, and mass spectrometry. Voltammetry at carbon-paste and glassy carbon electrodes showed that the oxidations proceed by an ECE or DISPI pathway. The rate-determining step is the reaction of water with a cation radical electrochemically generated from 1 or 2, involving either proton abstraction or nucleophilic addition. |
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Keywords: | Authors to whom correspondence should be addressed |
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