Gas chromatographic-mass spectrometric methods of analysis for detection of 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid in biological matrices.

Gas chromatographic-mass spectrometric methods of analysis for the detection of 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid, a major metabolite of delta 9-tetrahydrocannabinol, are reviewed. Emphasis is on analytical methodology including numerous derivatization techniques developed specifically for this analyte. The majority of procedures cited in the literature were developed to detect this metabolite in the blood and urine of man.