Synthetic anthracyclines: regiospecific total synthesis of a D-ring indole analogue of daunomycin |
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| Authors: | Y Kita M Kirihara M Sasho Y Fujii J Sekihachi R Okunaka Y Tamura K Shimooka |
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| Institution: | Faculty of Pharmaceutical Sciences, Osaka University, Japan. |
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| Abstract: | The 4-methoxy-5-methylpyrano4,3-b]indole-1,3(4H,5H)-dione (9), prepared from methyl 3-methoxycarbonyl-1-methylindol-2-yl acetate (6), underwent a strong base-induced cycloaddition reaction with 2-chloro-6,6-ethylenedioxy-5,6,7,8-tetrahydro-1,4-naphthoquinone (11) to give the tetrahydronaphtho2,3-b]carbazole-7,12-dione (10), regioselectively. The cycloadduct (10) was successfully converted to a D-ring indole analogue of daunomycin (1a). |
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