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Covalent anchoring of a racemization catalyst to CALB-beads: towards dual immobilization of DKR catalysts |
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| Authors: | Birgit Wieczorek Annika TräffPatrik Krumlinde Harm P DijkstraMaarten R Egmond Gerard van Koten Jan-Erling Bäckvall Robertus JM Klein Gebbink |
| Institution: | a Organic Chemisty & Catalysis, Debye Institute for Nanomaterials Research, Utrecht University, Padulaan 8, 3584 CH Utrecht, The Netherlands b Department of Organic Chemistry, Stockholm University, Arrhenius Laboratoriet, SE-106 91 Stockholm, Sweden c Membrane Enzymology, Bijvoet Center for Biomolecular Research, University of Utrecht, Padulaan 8, 3584 CH Utrecht, The Netherlands |
| Abstract: | The preparation of a heterogeneous bifunctional catalytic system, combining the catalytic properties of an organometallic catalyst (racemization) with those of an enzyme (enantioselective acylation) is described. A novel ruthenium phosphonate inhibitor was synthesized and covalently anchored to a lipase immobilized on a solid support (CALB, Novozym® 435). The immobilized bifunctional catalytic system showed activity in both racemization of (S)-1-phenylethanol and selective acylation of 1-phenylethanol. |
| Keywords: | Bifunctional catalytic system Metalloenzyme DKR Lipases Heterogeneous catalysis |
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