TBAI/TBHP‐Promoted Generation of Malonyl Radicals: Oxidative Coupling with Styrenes Leads to γ‐Keto Diesters |
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| Authors: | Soumyadeep Roy Chowdhury Injamam Ul Hoque Dr Soumitra Maity |
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| Institution: | Department of Applied Chemistry, Indian Institute of Technology (ISM) Dhanbad, Dhanbad, JH, India |
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| Abstract: | A metal‐free protocol for oxidative coupling of malonic esters with styrenes to form γ‐keto diesters has been developed. Key to the success of this process is the generation of malonyl radicals from unfunctionalized malonic esters under organo‐catalysis conditions with TBAI and TBHP. This process tolerates both terminal and internal olefins with diverse malonic esters. It provides a new green metal‐free alternative to traditional metal mediated process for generation of malonyl radicals and there by γ‐keto diesters. |
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| Keywords: | ketodiester malonyl radical metal-free conditions oxidative coupling TBAI/TBHP |
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