Asymmetric “Acetylenic” [3+2] Cycloaddition of Nitrones Catalyzed by Cationic Chiral PdII Lewis Acid |
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| Authors: | Dr Kazuya Honda Prof?Dr Koichi Mikami |
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| Institution: | Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo, Japan |
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| Abstract: | Highly enantioselective 3+2] cycloaddition of ynones and nitrones has been developed. Very bulky ligand, DTBM‐SEGPHOS, was used for an effective asymmetric induction over distal reaction centers on the linear ynone dipolarophile and for prevention of PdII catalyst deactivation by coordination of the nitrones. The reaction has wide scope of substrates in both ynones and nitrones. |
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| Keywords: | alkynes computational chemistry cycloaddition palladium synthetic methods |
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