Orthogonally Protected, Carboxy-Activated L-Homoisoserine, 2-Methyl-L-homoisoserine, and Homoisocysteine Derivatives. New Building Blocks for Peptide and Depsipeptide Modification |
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| Authors: | Klaus Burger Gabor Radics Lothar Hennig Christoph B?ttcher Jan Spengler Fernando Albericio |
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| Affiliation: | (1) School of Engineering and Computer Science, Victoria University of Wellington, PO Box 600, Wellington, New Zealand;(2) School of Mathematics, Statistics and Operations Research, Victoria University of Wellington, PO Box 600, Wellington, New Zealand |
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| Abstract: | Starting from L-malic, L-citramalic, and rac. thiomalic acids routes to L-homoisoserine, 2-methyl-L-homoisoserine and rac. homoisocysteine have been developed. The new orthogonally protected and carboxy-activated building blocks are GABA as well as  -hydroxy and -mercapto acid derivatives, suitable for the construction of peptide and depsipeptide surrogates. |
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