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Facile Synthesis of Dihydro-1,2,4-benzotriazepin-5-ones |
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| Authors: | Nisreen I. Hindawi Jalal A. Zahra Mustafa M. El-Abadelah Bassam A. Abu Thaher Klaus-Peter Zeller |
| Affiliation: | Chemistry Department, Faculty of Science, University of Jordan, Amman, Jordan Chemistry Department, Faculty of Science, Islamic University of Gaza, Gaza Strip Institut für Organische Chemie, Universit?t Tübingen, Tübingen, Germany |
| Abstract: | Summary. Direct interaction between model anilines and an 1,3-dipolar nitrile imine, derived from 2-[N′-(1-chloro-2-oxopropylidine)hydrazine]benzoic acid, yielded the respective acyclic amidrazones. The latter adducts underwent CDI-induced cyclocondensation involving the hydrazone–NH terminus and the activated carboxy group to produce the corresponding dihydro-1,2,4-benzotriazepin-5-ones. |
| Keywords: | . N-(2-Carboxyphenyl)hydrazonoyl chloride 1,3-Nucleophilic addition N-Arylamidrazones Cyclization Dihydro-1,2,4-benzotriazepin-5-ones. |
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