New cytotoxic bicyclic hexapeptides, RA-XXIII and RA-XXIV, from Rubia cordifolia L |
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Authors: | Lee Ji-Ean Hitotsuyanagi Yukio Fukaya Haruhiko Kondo Kazuyuki Takeya Koichi |
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Affiliation: | School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan. |
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Abstract: | Two new bicyclic hexapeptides, RA-XXIII and RA-XXIV, were isolated from the roots of Rubia cordifolia L. (Rubiaceae). Their structures were determined by the analysis of their 2D NMR spectra, chemical methods, and X-ray crystallography. The IC50 values of RA-XXIII and RA-XXIV against P-388 leukemia cells were 0.16 and 0.48 microg/ml, respectively. |
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