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Palladium catalyzed alkylation of indole via aliphatic C-H bond activation of tertiary amine |
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| Authors: | K. RamachandiranD. Muralidharan P.T. Perumal |
| Affiliation: | Organic Chemistry Division, Central Leather Research Institute (CSIR), Adyar, Chennai 600 020, India |
| Abstract: | Alkylation of indoles has been achieved via Pd-catalyzed aliphatic C-H bond activation of tertiary amine coupling with indole followed by C-N bond cleavage and subsequent addition of indole. This method involves the migration of alkane chain from tertiary amine to indole. |
| Keywords: | Palladium C-H activation 1,1-Bis-indolymethane C-C coupling Alkylation of indole |
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