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A de novo Diels-Alder strategy toward the novel pentacyclic natural product fluostatin C: a concise synthesis of 6-deoxyfluostatin C |
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| Authors: | Goverdhan Mehta YC Sunil KumarManabendra Das |
| Institution: | a Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India b School of Chemistry, University of Hyderabad, Hyderabad 500046, India |
| Abstract: | A conceptually new Diels-Alder approach, involving a diene moiety grafted on a preformed epoxyquinone platform and a 4-hydroxy-indenone as the dienophile, delivers the pentacyclic framework of fluostatin C in one key step. |
| Keywords: | Natural product synthesis Cytostatic agents Diels-Alder reaction Regioselectivity Aromatization |
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