Integrated microthermoelectric cooler for microfluidic channels

Precise fluid temperature control in microfluidic channels is a requirement for many lab-on-a-chip and microreactor devices, especially in biotechnology where most processes are highly temperature sensitive. We demonstrate the concept of a microthermoelectric cooler integrated into a microfluidic channel in order to give rapid and localised fluid cooling. The key aspect of this concept is the use of a second imbedded microfluidic channel that is used as a miniature heat sink. An analytical thermal model has been derived that couples thermoelectric effects with fluid heat-transfer rates from both the hot and cold connections. Using this model, the effect on cooling performance of varying the thermal resistance between the hot and cold connections and the fluid has been quantified, as well as the effect of substrate thermal conductivity. If the substrate thermal conductivity is too high, heat leakage renders the thermoelectric cooler ineffective. The optimum electrical current for cooling has been shown to be a function of the thermal resistance of the heat sink. For thermoelectric coolers there is competition between temperature reduction and cooling power. Using this fact, based on the final fluid temperature required, we have calculated the maximum flow rate that will achieve this. Finally, a prototype integrated microthermoelectric cooler has been fabricated and tested.