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Electrochemical Nickel-Catalyzed Selective Inter- and Intramolecular Arylations of Cysteine-Containing Peptides** |
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| Authors: | Linhua Shen Olivier Monasson Elisa Peroni Franck Le Bideau Samir Messaoudi |
| Affiliation: | 1. Université Paris-Saclay, CNRS, BioCIS, 92290 Orsay, France;2. Université Paris-Saclay, CNRS, BioCIS, 92290 Orsay, France CY Cergy Paris Université, CNRS, BioCIS, 95000 Cergy Pontoise, France |
| Abstract: | Here we report a simple electrochemical route towards the synthesis of S-arylated peptides by a site selective coupling of peptides with aryl halides under base free conditions. This approach demonstrates the power of electrochemistry to access both highly complex peptide conjugates and cyclic peptides. |
| Keywords: | Cyclic Peptides Electrochemistry Nickel Peptides S-Arylated Cysteine |