Novel Ring Systems: Spiro[Cycloalkane] Derivatives of Triazolo- and Tetrazolo-Pyridazines |
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Authors: | Csilla Sepsey Für Gerg Riszter ron SzigetvrI Mikls Dkny Gyrgy Keglevich Lszl HazaI Hedvig BlcskeI |
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Institution: | 1.Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Hungary; (C.S.F.); (G.R.); (G.K.); (L.H.);2.Gedeon Richter Plc. Budapest X, Gyömrői út 19-21, 10 P.O. Box 27, H-1475 Budapest, Hungary; (Á.S.); (M.D.) |
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Abstract: | In orderto synthesize new pyridazine derivatives anellated with different nitrogen heterocyclic moieties, spirocycloalkane]pyridazinones were transformed into the corresponding thioxo derivatives via a reaction with phosphorus pentasulfide. The reaction of the formed 2,3-diazaspiro5.5]undec-3-ene-1-thiones with hydrazine provided the corresponding 1-hydrazono-2,3-diazaspiro5.5]undec-3-ene, whose diazotization led to the desired spirocyclohexane-1,8′-tetrazolo1,5-b]pyridazines. The reaction of dihydropyridazinethiones with benzhydrazide afforded the corresponding 7H-spiro1,2,4]triazolo4,3-b]pyridazin-8,1′-cyclohexanes]. As a result of our work, seven new pyridazinethione intermediates were prepared, which served as starting materials for the synthesis of two kinds of new ring systems: tetrazolo-pyridazines and triazolo-pyridazines. The six new annulated derivatives were characterized by physicochemical parameters. The new N-heterocycles are valuable members of the large family of pyridazines. |
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Keywords: | N-heterocycles pyridazine derivatives thionation diazotization triazolo-pyridazines tetrazolo-pyridazines |
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