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Synthesis and functional pharmacological effects on human bronchi of 20-hydroxyeicosatetraenoic acid |
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| Authors: | A. Proteau-Gagne F. St-Jean C. Morin L. Gendron E. Rousseau Y. L. Dory |
| Affiliation: | (1) Laboratory of Supramolecular Synthesis, Department of Chemistry, Institute of Pharmacology, University of Sherbrooke, 3001 avenue nord, Sherbrooke, Qc J1H 5N4, Canada;(2) Le Biliarium, Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, University of Sherbrooke, 3001 12e avenue nord, Sherbrooke, Qc J1H 5N4, Canada; |
| Abstract: | We have synthesized 20-hydroxyeicosatetraenoic acid (20-HETE) following a new route and delineated its functional effects in human bronchi. Isometric tension measurements were performed, and they demonstrated that synthetic 20-HETE induced a concentration-dependent relaxant effect in ASM on resting tone and on bronchi pre-contracted with methacholine. |
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