Separation of isomers <Emphasis Type="Italic">L</Emphasis>-alanine and sarcosine in urine by electrospray ionization and tandem differential mobility analysis-mass spectrometry |
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Authors: | Pablo Martínez-Lozano Juan Rus |
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Institution: | 1.Institute for Biomedical Technologies-National Research Council,Segrate,Italy;2.SEADM,Valladolid,Spain |
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Abstract: | Sarcosine, an isomer of L-alanine, has been proposed as a prostate cancer progression biomarker 1]. Both compounds are detected in urine, where the
measured sarcosine/alanine ratio has been found to be higher in prostate biopsy-positive group versus controls. We present
here preliminary evidence showing that urine samples spiked with sarcosine/alanine can be partially resolved in 3 min via
tandem differential mobility analysis-mass spectrometry (DMA-MS). Based on the calibration curves obtained for two mobility
peaks, we finally estimate their concentration ratio in urine. |
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