A facile approach to substituted acrylates by regioselective and stereoselective addition of thiols and amines to an alkynyl ester in water |
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| Authors: | Nitin A Randive Varun Kumar and Vipin A Nair |
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| Institution: | (1) Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, Mohali, Punjab, 160062, India; |
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| Abstract: | Abstract Water-promoted hydrothiolation and hydroamination of ethyl propiolate leading to highly regioselective and stereoselective
formation of thioacrylates and β-enamino esters in excellent yields, by a simple, efficient, and environmentally friendly
reaction procedure without employing any hazardous reagent or solvent is reported. |
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