| N-甲基吡咯烷酮作为一碳合成子在曼尼希反应中的应用 |
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| 引用本文： | 王薪,孙凯.N-甲基吡咯烷酮作为一碳合成子在曼尼希反应中的应用[J].应用化学,2017,34(5):534-540. |
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| 作者姓名： | 王薪 孙凯 |
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| 作者单位： | 安阳师范学院化学化工学院 河南 安阳 455000 |
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| 基金项目： | 国家自然科学基金资助项目(U1504210),吉林省有机功能分子设计与合成重点实验室资助项目(130028651) |
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| 摘 要： | 以苯乙酮衍生物为原料,N-甲基吡咯烷酮替代甲醛类似物,考察了其作为一碳合成子在曼尼希反应中的应用。在最优条件下,以46%~93%的收率成功合成了系列曼尼希碱衍生物。该反应底物范围宽泛,官能团兼容性好,并且初步研究了该反应的机理。
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| 关 键 词： | 曼尼希碱 N-甲基吡咯烷酮 一碳合成子 C—C键形成 C—N键形成 |
| 收稿时间： | 2016-07-12 |
Application of N-Methyl-2-pyrrolidinone as One Carbon Synthon in Mannich Reactions |
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| WANG Xin,SUN Kai.Application of N-Methyl-2-pyrrolidinone as One Carbon Synthon in Mannich Reactions[J].Chinese Journal of Applied Chemistry,2017,34(5):534-540. |
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| Authors: | WANG Xin SUN Kai |
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| Institution: | College of Chemistry and Chemical Engineering,Anyang Normal University,Anyang,He'nan 455000,China |
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| Abstract: | With acetophenone derivatives as raw materials, we reported the application of N-methyl-2-pyrrolidone as one carbon synthon to replace formaldehyde analogues in the Mannich reaction. Under optimal reaction conditions, a series of mannich base derivatives were obtained with 46%~93% yield. This reaction shows a broad substrate scope and good functional groups compatibility. The preliminary mechanism of the reaction was also studied. |
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| Keywords: | Mannich base N-methyl-pyrrolidinone one carbon synthon C—C bond formation C—N bond formation |
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