| 无溶剂硼酸高效合成螺杂双环衍生物 |
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| 引用本文： | 许招会,刘德勇,涂缘鸿.无溶剂硼酸高效合成螺杂双环衍生物[J].应用化学,2015,32(9):999-1004. |
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| 作者姓名： | 许招会 刘德勇 涂缘鸿 |
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| 作者单位： | 江西师范大学国家单糖化学合成工程技术研究中心 南昌 330027 |
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| 基金项目： | 国家科技攻关计划(2001BA323C);江西省研究生创新基金(YC2015-B030)资助项目 |
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| 摘 要： | 在硼酸催化下,芳香醛、尿素和2,2-二甲基-1,3-二噁烷-4,6-二酮在无溶剂条件下合成了8种螺杂双环衍生物。 当催化剂的用量为10%(摩尔分数)时,80 ℃反应2.0~4.0 h,收率为74%~93%。 此外,还探讨了硼酸可能的催化机理。 该方法具有条件温和,后处理工艺简单及收率高的优点。
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| 关 键 词： | 硼酸 无溶剂 三组分反应 螺杂双环衍生物 |
| 收稿时间： | 2015-02-02 |
Efficient Solvent-free Synthesis of Spiro Heterobicyclic Derivatives with Boric Acid as Catalyst |
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| XU Zhaohui,LIU Deyong,TU Yuanhong.Efficient Solvent-free Synthesis of Spiro Heterobicyclic Derivatives with Boric Acid as Catalyst[J].Chinese Journal of Applied Chemistry,2015,32(9):999-1004. |
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| Authors: | XU Zhaohui LIU Deyong TU Yuanhong |
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| Institution: | National Monosaccharide Chemical Synthesis Engineering Research Center, Jiangxi Normal University,Nanchang 330027,China |
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| Abstract: | Eight spiro heterobicyclic compounds were synthesized by the three component condensation reaction of aromatic aldehydes with urea and 2,2-dimethyl-1,3-dioxane-4,6-dione using boric acid as catalyst under solvent-free conditions. The results indicate that the yields range from 84% to 94% at 80 ℃ for 2.0~4.0 h using 10% molar fraction of boric acid(relative to the substrate of 2,2-dimethyl-1,3-dioxane-4,6-dione). Furthermore, a mechanism for the reaction catalyzed by boric acid was proposed. The main advantages of the present procedure are mild conditions, short reaction time and high yields. |
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| Keywords: | boric acid solvent-free three component condensation reaction spiro heterobicyclic derivatives |
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